Simona Samland

Bachelorstudentin

Surface-modified mesoporous bioactive glass nanoparticles for tissue engineering applications

Supervisors: Andrada-Ioana Damian-Buda, Prof. Andreas Arkudas, Prof. Aldo R. Boccaccini

Mesoporous bioactive glass nanoparticles (MBGNs) stand out for tissue engineering applications due to their high surface area, controlled mesoporous structure, and ability to release therapeutic ions [1]. However, their performance in biological environments is directly related to the surface properties, especially chemical composition and charge [2]. To tailor these interactions, this bachelor’s thesis will focus on the development of organic molecule functionalized MBGNs, followed by further surface modification. The obtained MBGNs will be characterized in detail in terms of morphology, surface area, surface chemistry, degradation behaviour, ion release in different media, and protein adsorption, aiming to evaluate the influence of surface modification on MBGNs‘ physicochemical properties and biological interactions.

[1] Vallet-Regí, M.; Salinas, A. J. Mesoporous Bioactive Glasses for Regenerative Medicine. Materials Today Bio 2021, 11, 100121, doi:10.1016/j.mtbio.2021.100121.

[2] Damian-Buda, A.-I.; Boccaccini, A. R. Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature. Advanced Healthcare Materials 2026, 15(1), 2502754, doi:10.1002/adhm.202502754.