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Mesoporous bioactive glass particles for localized release of therapeutic ions and drugs

Betreuer: Prof. Dr. –Ing. habil. Aldo R. Boccaccini

This research project involves the synthesis of mesoporous bioactive glass nanoparticles as smart platforms for effective, non-invasive and highly targeted therapies to treat delayed bone healing and non-healing chronic skin wounds. For this purpose, mesoporous glasses are doped with specific ions which play additional roles in osteogenesis, angiogenesis and antibacterial applications [1]. Surface morphology, pore size distribution, bioactivity and in vitro cytocompatibility of the synthesized inorganic nanomatrices will be characterized. The project is being carried out in the framework of the EU funded project „MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs (MOZART)“

[1] A. Hoppe, V. Mouriño, and A.R. Boccaccini, “Therapeutic inorganic ions in bioactive glasses to enhance bone formation and beyond,” Biomater. Sci., 1 [3] 254–256 (2013).

Zeitraum: 2013 – 2016 (Dokrorand)

Thema / Repräsentative Veröffentlichung:

Surface modification of bioactive glass scaffolds

P. Balasubramanian, L. Hupa, B. Jokic, R. Detsch, A. Grünewald, and A.R. Boccaccini, „Angiogenic potential of boron-containing bioactive glasses: in vitro study,“ J. Mater. Sci., in press (2017)

weitere Informationen: Zur Zeit: PostDoc am Lehrstuhl  Biomaterialien, Universität Erlangen-Nürnberg

 

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