Nadine Bingöl
Nadine Bingöl
Bachelorstudentin
Evaluation of the impact of pre-heated gelatin on the printability, microporosity and cell-material-interactions in ADA-GEL hydrogels for biofabrication
Betreuer: Jonas Röder, Prof. Aldo R. Boccaccini
In previous studies it was found that heat treated gelatin can be mixed into ADA-GEL hydrogels to function as a porogen due to its faster release and increased degradation [1]. In the scope of this work the effect of heat-treated gelatin on the printability and microporosity of ADA-GELs shall be assessed. The most favorable combinations will be further investigated in relation to microstructure and cell-material interaction using histological techniques. The final objective of this Bachelor thesis is thus to identify the key factors contributing to optimal printability while providing a suitable environment for cell proliferation.
[1] Kreller, T. et al. Physico-chemical modification of gelatine for the improvement of 3D printability of oxidized alginate-gelatine hydrogels towards cartilage tissue engineering. Mater. Des. 208, 109877 (2021).