pH-Sensitive nanofibrous materials for wound healing
Investigator: Maximilian Meuter (Master Student, am INTEMA, Mar del Plata, Argentinien)
Betreuer in Mar del Plata: Dr. Gustavo A. Abraham and Dr. Guadalupe Rivero
Betreuer in Erlangen: Dr. Liliana Liverani, Prof. Dr.-Ing. habil. Aldo R. Boccaccini
This project aims at developing a pH-sensitive wound dressing including controlled drug delivery for superficial wounds by solvent-based uniaxial electrospinning of suitable polymers. pH-Responsive, biocompatible and biodegradable polymers will be chosen, which show dissolution above pH 7. Due to disorders in the physical balance between tissue formation and degradation during the inflammatory phase in wounds, pH-changes from acidic to alkaline milieu occur, thus polymers which are pH sensitive can be used as a trigger for controlled drug release. The study will investigate suitable solvents for electrospinning, including acetone, ethanol, dimethylformamide and mixtures of them. Physical and antibacterial properties of the new fibrous dressings will be characterized. The project is a collaboration between the Division of Biomedical Polymers at the Research Institute for Materials Science and Technology, INTEMA, University of Mar del Plata, Argentina, led by Dr. Gustavo Abraham, and the FAU Institute of Biomaterials. The project is part of the I.DEAR students exchange program of the Argentinian-German University Centre (DAHZ-CUAA).