Jéssica Cardinali

Visiting researcher, Santa Catarina State University, Brazil

Polymer-bioactive glass composites for tissue engineering

Supervisor in Brazil: Prof. Daniela Becker

Supervisor in Erlangen: Prof. Aldo R. Boccaccini

3D scaffolds are widely investigated in bone tissue engineering as synthetic platforms to support regeneration by providing a temporary structure for cell attachment and tissue ingrowth [1]. In this project, bioactive glass particles are incorporated in biodegradable polymers to improve scaffold bioactivity and interfacial performance [2]. Two compositions are explored: Bioglass® 45S5 and Biosilicate®, the particles are functionalized with APTES via plasma. Posteriorly, scaffolds produced by Melt electrowriting (MEW) will be coated with the particles through dip coating. The project is supported by the Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC), Brazil.

[1] Hum J, Boccaccini AR. Collagen as Coating Material for 45S5 Bioactive Glass-Based Scaffolds for Bone Tissue Engineering. Int J Mol Sci. 2018 Jun 19;19(6):1807. doi: 10.3390/ijms19061807. PMID: 29921804; PMCID: PMC6032265.

[2] Gorustovich AA, Roether JA, Boccaccini AR. Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences. Tissue Eng Part B Rev. 2010 Apr;16(2):199-207. doi: 10.1089/ten.TEB.2009.0416. PMID: 19831556.