Franziska Noß

Master student

Electrospun PCL-Chitosan based nanofibres containing mesoporous bioactive glass nanoparticles incorporating phytotherapeutics for wound dressings

Supervisors: Dulce Medina Bueno, Prof. Aldo R. Boccaccini

This master thesis investigates scaffolds in form of nanofibrous meshes, produced by electrospinning technique, regarding their physical, chemical and mechanical properties, antibacterial and antioxidant activity, as well as their drug delivery ability, swelling and degradation behaviour, water vapor transmission rate and further more. Mesoporous bioactive glass nanoparticles (MBGNs) reduce infections, regulate inflammatory processes, promote cell proliferation and stimulate angiogenesis [1]. The mesoporous nanoparticle form enables controlled release of antibacterial ions and incorporated natural therapeutic agents, such as plan derived compounds, that significantly improve wound healing by their antibacterial, anti-inflammatory and antioxidative properties [2]. In this study, new combinations of MBGNs and phytotherapeutics will therefore be investigated.

[1] Boccaccini AR, Erol-Taygun M, Stark WJ, Mohn D, Hong Z, Mano JF. (2010) Polymer/bioactive glass nanocomposites for biomedical applications: a review. Compos Sci Technol; 70:1764–76. http://dx.doi.org/10.1016/j.compscitech.2010.06.002.

[2] Pourshahrestani, S., Zeimaran, E., Janko, C., Alexiou, C., Kerpes, A., Würz, A., Fischer, M., Kaňková, H., Hartmann, M., & Boccaccini, A. R. (2024). The effect of mesoporous bioactive glass nanoparticles incorporating various metallic ions (Cu, Zn, Mn, Te) on wound healing. Materials Advances, 5(16), 6630–6647. https://doi.org/10.1039/d4ma00392f