Euna Song

Bachelor student

Electrophoretic deposition (EPD) and characterization of composite coatings incorporated with Sr-doped bioactive glass nanoparticles for orthopedic implants

 

Supervisors: Rezvan Azari, Prof. Aldo R. Boccaccini

Bioactive glass particles have been extensively utilized in regenerative therapies as they facilitate bonding through hydroxyapatite formation and provide a biocompatible environment for bone regeneration. Among various dopant ions investigated to improve the therapeutic performance of bioactive glasses, strontium (Sr) has attracted attention due to its dual effect of promoting osteoblast activity and inhibiting osteoclasts [1]. To effectively apply such functionalized particles onto the surface of metallic implants, electrophoretic deposition (EPD) offers a versatile and efficient deposition method with precise control over the thickness and morphology of the coatings [2]. Based on these considerations, this project aims to synthesize and characterize Sr-doped bioactive glass nanoparticles using the sol-gel process [3] and to apply them as coatings on titanium substrates via EPD.

[1] D. Bahati, M. Bricha, and K. El Mabrouk, “Synthesis, characterization, and in vitro apatite formation of strontium-doped sol-gel-derived bioactive glass nanoparticles for bone regeneration applications,” Ceram. Int., vol. 49, no. 14, pp. 23020–23034, 2023, doi: 10.1016/j.ceramint.2023.04.128.

[2] B. Hoomehr, K. Raeissi, F. Ashrafizadeh, S. Labbaf, and M. Kharaziha, “Electrophoretic deposition of bioactive glass/zirconia core-shell nanoparticles on Ti6Al4V substrate,” Ceram. Int., vol. 47, no. 24, pp. 34959–34969, Dec. 2021, doi: 10.1016/j.ceramint.2021.09.037.

[3] K. Zheng and A. R. Boccaccini, “Sol-gel processing of bioactive glass nanoparticles: A review,” Adv. Colloid Interface Sci., vol. 249, pp. 363–373, 2017, doi: 10.1016/j.cis.2017.03.008.