Gaststudentin, University Politehnica of Bucharest, Romania
Development of new compositions of sol-gel derived ion doped bioactive glasses with angiogenic potential for hard tissue engineering
Betreuer: Qaisar Nawaz, Prof. Aldo R. Boccaccini
The intrinsic ability of hard tissue to regrow and restore itself as part of the bone physiological remodelling process is already well-understood; however, when a large amount of tissue is affected, this process becomes restricted. To overcome this problem, bioactive materials are required, of which bioactive glasses, developed for the first time 50 years ago, represent a very good example . One of the main problems of tissue engineered constructs is the lack of vascular supply to transport nutrients and metabolic waste . To address this challenge, bioactive glasses with the capability to release angiogenic ions are being developed . In this project, we aim to synthesise ion doped mesoporous bioactive glass nanoparticles (MBGN) using the sol-gel technique . Also, considering the porous structure of the natural bone tissue, 3D bioactive glass scaffolds will be synthesised via the foam replication method. The scaffolds will be coated with the angiogenic MBGNs, characterised and tested for biological activity.
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